Gene Knowledge Graph
UTC
Sensitive

Diabetes mellitus

HNF1A · rs893256143

Where this position leads

Condition: Gestational Diabetes Mellitus

rs893256143 Condition: Gestational Diabetes Mellitus Gestational Diabetes Mellitus Condition rs893256143 rs893256143 HNF1A

Strength of the evidence

4 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 3 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic for Diabetes mellitus, Monogenic diabetes, Maturity-onset diabetes of the young, Maturity-onset diabetes of the young type 3, HNF1A-related disorder; reviewed by expert panel (3 of 4 stars, 10 submitters), last evaluated 2022-04-10. ClinVar record 381588 NM_000545.8(HNF1A):c.599G>A (p.Arg200Gln)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version ClinVar lists as disease-causing for Diabetes mellitus. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. (ClinVar VCV000381588, reviewed by expert panel)
A/G One copy of the version ClinVar lists as disease-causing for Diabetes mellitus. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. (ClinVar VCV000381588, reviewed by expert panel)
G/G No copy of the version ClinVar lists as disease-causing for Diabetes mellitus. This is the usual result. (ClinVar VCV000381588, reviewed by expert panel)

Source: ClinVar VCV000381588, reviewed by expert panel

Questions about rs893256143

What is rs893256143?

rs893256143 is a single position in the genome, in or near the HNF1A gene. Published research associates it with diabetes mellitus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs893256143 linked to?

On MyGeneLog this position is linked to Gestational Diabetes Mellitus. The research behind each link, and its sources, are set out on that condition page.

Does having rs893256143 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs893256143 come from?

ClinVar VCV000381588, reviewed by expert panel. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Diabetes mellitus (rs893256143). MyGeneLog™. https://www.mygenelog.com/variants/rs893256143

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