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Who was studied 1,782 Admix African and African American ancestry cases, 9,356 Admix African and African American ancestry controls, 11,350 East Asian ancestry cases, 137,515 East Asian ancestry controls, 166,322 European ancestry cases, 1,313,950 European ancestry controls, 1,774 Hispanic or Latin American cases, 7,665 Hispanic or Latin American controls, 218 South Asian ancestry cases, 413 South Asian ancestry controls.
The effect
Each copy of the A allele carried 1.10 times the odds of Atrial fibrillation (95% confidence interval 1.09-1.11); p = 7 × 10−65.
How common The A allele had a frequency of about 22% in the people studied.
Where it sits Chromosome 2, band 2q31.2 — in a non-coding transcript of TTN.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-06-14.
ClinVar record 671418NM_001267550.2(TTN):c.91853-37G>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
rs890578 is a single position in the genome, in or near the TTN gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs890578 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs890578 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs890578 come from?
GWAS Catalog, Nature genetics 2025, PMID:40050429. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 21122115Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others15Total21Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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