Standard

Waist-to-hip ratio adjusted for BMI

MAPKBP1 · rs890498

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 379,501 European ancestry female individuals.

The effect Each copy of the C allele shifted the measure 0.0151 lower (95% confidence interval 0.011-0.019); p = 3 × 10⁻¹⁵.

How common The C allele had a frequency of about 66% in the people studied.

Where it sits Chromosome 15, band 15q15.1 — in an intron of MAPKBP1.

What ClinVar records

Classification Benign for Malignant lymphoma, large B-cell, diffuse, Uveal melanoma; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2021-05-13. ClinVar record 1182734 NM_014994.3(MAPKBP1):c.2291+143C>G

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Waist-to-hip ratio adjusted for BMI compared to the general population.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Waist-to-hip ratio adjusted for BMI.

G/G Published research associates this genotype with typical/baseline likelihood of Waist-to-hip ratio adjusted for BMI — no copies of the reported risk allele.

Source

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, Yang J, Jones S

and 10 more — show all

Beaumont R, Croteau-Chonka DC, Winkler TW, Hattersley AT, Loos RJF, Hirschhorn JN, Visscher PM, Frayling TM, Yaghootkar H, Lindgren CM

GIANT Consortium

Human molecular genetics · 2019 · PMID 30239722 · open access

Questions about rs890498

What is rs890498?

rs890498 is a single position in the genome, in or near the MAPKBP1 gene. Published research associates it with waist-to-hip ratio adjusted for bmi. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs890498 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs890498 come from?

GWAS Catalog, Human molecular genetics 2019, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Waist-to-hip ratio adjusted for BMI (rs890498). MyGeneLog™. https://www.mygenelog.com/variants/rs890498

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