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Benign prostatic hyperplasia and lower urinary tract symptoms

TBX3 · rs8853

Where this position leads

Condition: Benign Prostatic Hyperplasia

rs8853 Condition: Benign Prostatic Hyperplasia Benign Prostatic Hyperplasia Condition rs8853 rs8853 TBX3

What the study found

Who was studied 20,621 European ancestry cases, 280,541 European ancestry controls.

The effect Each copy of the C allele carried 1.07 times the odds of Benign prostatic hyperplasia and lower urinary tract symptoms (95% confidence interval 1.05-1.09); p = 4 × 10−9.

How common The C allele had a frequency of about 49% in the people studied.

Where it sits Chromosome 12, band 12q24.21 — in the 3′ untranslated region of TBX3.

What ClinVar records

Classification Benign for Ulnar-mammary syndrome; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-01-13. ClinVar record 307336 NM_005996.4(TBX3):c.*739A>G

What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Benign prostatic hyperplasia and lower urinary tract symptoms compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Benign prostatic hyperplasia and lower urinary tract symptoms.
T/T Published research associates this genotype with typical/baseline likelihood of Benign prostatic hyperplasia and lower urinary tract symptoms — no copies of the reported risk allele.
Source
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA
Gudmundsson J, Sigurdsson JK, Stefansdottir L, Agnarsson BA, Isaksson HJ, Stefansson OA, Gudjonsson SA, Gudbjartsson DF, Masson G, Frigge ML, Stacey SN, Sulem P
and 16 more — show all
Halldorsson GH, Tragante V, Holm H, Eyjolfsson GI, Sigurdardottir O, Olafsson I, Jonsson T, Jonsson E, Barkardottir RB, Hilmarsson R, Asselbergs FW, Geirsson G, Thorsteinsdottir U, Rafnar T, Thorleifsson G, Stefansson K
Nature communications · 2018 · PMID 30410027 · open access

Questions about rs8853

What is rs8853?

rs8853 is a single position in the genome, in or near the TBX3 gene. Published research associates it with benign prostatic hyperplasia and lower urinary tract symptoms. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8853 linked to?

On MyGeneLog this position is linked to Benign Prostatic Hyperplasia. The research behind each link, and its sources, are set out on that condition page.

Does having rs8853 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8853 come from?

GWAS Catalog, Nat Commun 2018, PMID:30410027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Benign prostatic hyperplasia and lower urinary tract symptoms (rs8853). MyGeneLog™. https://www.mygenelog.com/variants/rs8853

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