GnT-IVa · rs885036
Where this position leads
Condition: Colorectal Cancer
Strength of the evidence
Its strongest genetic-study result is p = 10−8.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 256 cases treated with CAPOX-B plus cetuximab, 264 cases treated with CAPOX-B.
The effect Each copy of the A allele carried 2.13 times the odds of Progression free survival in metastatic colorectal cancer (chemotherapy interaction) (95% confidence interval 1.64-2.78); p = 2 × 10−8.
Where it sits Chromosome 2, band 2q11.2 — in an intron of MGAT4A.
rs885036 is a single position in the genome, in or near the GnT-IVa gene. Published research associates it with progression free survival in metastatic colorectal cancer (chemotherapy interaction). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, PLoS One 2015, PMID:26222057. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Progression free survival in metastatic colorectal cancer (chemotherapy interaction) (rs885036). MyGeneLog™. https://www.mygenelog.com/variants/rs885036