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Osteoporosis

LRP5 · rs880610

Where this position leads

Condition: Osteoporosis

rs880610 Condition: Osteoporosis Osteoporosis Condition rs880610 rs880610 LRP5

What the study found

Who was studied 8,520 European ancestry cases, 479,981 European ancestry controls, 9,794 East Asian ancestry cases, 168,932 East Asian ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0843 higher (95% confidence interval 0.057-0.112); p = 2 × 10−9.

Where it sits Chromosome 11, band 11q13.2 — in an intron of LRP5.

What each result means

A/A Two copies of the version the research linked to Osteoporosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Osteoporosis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Osteoporosis. This is the starting point the study compared everyone against.
Source

Questions about rs880610

What is rs880610?

rs880610 is a single position in the genome, in or near the LRP5 gene. Published research associates it with osteoporosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs880610 linked to?

On MyGeneLog this position is linked to Osteoporosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs880610 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs880610 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Osteoporosis (rs880610). MyGeneLog™. https://www.mygenelog.com/variants/rs880610

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