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Stroke (ischemic)

ZFHX3 · rs879324

Where this position leads

Condition: Ischaemic Stroke

rs879324 Condition: Ischaemic Stroke Ischaemic Stroke Condition rs879324 rs879324 ZFHX3

What the study found

Who was studied 12,389 European ancestry cases, 62,004 European ancestry controls; replicated in 1,322 Pakistani ancestry cases, 1,143 Pakistani ancestry controls, 12,025 European ancestry cases, 27,940 European ancestry controls.

The effect Each copy of the A allele carried 1.25 times the odds of Stroke (ischemic) (95% confidence interval 1.15-1.35); p = 2 × 10−8.

How common The A allele had a frequency of about 19% in the people studied.

Where it sits Chromosome 16, band 16q22.3 — in an intron of ZFHX3.

What each result means

A/A Two copies of the version the research linked to Stroke (ischemic). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Stroke (ischemic). That is a smaller link than two copies.
G/G No copy of the version the research linked to Stroke (ischemic). This is the starting point the study compared everyone against.
Source
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies
Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng YC, Fornage M, Ikram MA, Malik R, Bevan S, Thorsteinsdottir U, Nalls MA
and 70 more — show all
Longstreth W, Wiggins KL, Yadav S, Parati EA, Destefano AL, Worrall BB, Kittner SJ, Khan MS, Reiner AP, Helgadottir A, Achterberg S, Fernandez-Cadenas I, Abboud S, Schmidt R, Walters M, Chen WM, Ringelstein EB, O'Donnell M, Ho WK, Pera J, Lemmens R, Norrving B, Higgins P, Benn M, Sale M, Kuhlenbäumer G, Doney AS, Vicente AM, Delavaran H, Algra A, Davies G, Oliveira SA, Palmer CN, Deary I, Schmidt H, Pandolfo M, Montaner J, Carty C, de Bakker PI, Kostulas K, Ferro JM, van Zuydam NR, Valdimarsson E, Nordestgaard BG, Lindgren A, Thijs V, Slowik A, Saleheen D, Paré G, Berger K, Thorleifsson G, Hofman A, Mosley TH, Mitchell BD, Furie K, Clarke R, Levi C, Seshadri S, Gschwendtner A, Boncoraglio GB, Sharma P, Bis JC, Gretarsdottir S, Psaty BM, Rothwell PM, Rosand J, Meschia JF, Stefansson K, Dichgans M, Markus HS
Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2) · International Stroke Genetics Consortium
The Lancet. Neurology · 2012 · PMID 23041239 · open access

Questions about rs879324

What is rs879324?

rs879324 is a single position in the genome, in or near the ZFHX3 gene. Published research associates it with stroke (ischemic). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs879324 linked to?

On MyGeneLog this position is linked to Ischaemic Stroke. The research behind each link, and its sources, are set out on that condition page.

Does having rs879324 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs879324 come from?

GWAS Catalog, Lancet Neurol 2012, PMID:23041239. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Stroke (ischemic) (rs879324). MyGeneLog™. https://www.mygenelog.com/variants/rs879324

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