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Telomere length (principal component 1)

XPO7 · rs878873

What the study found

Who was studied 438,351 Non-Finnish European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.026 higher (95% confidence interval 0.022-0.03); p = 3 × 10−38.

How common The T allele had a frequency of about 44% in the people studied.

Where it sits Chromosome 8, band 8p21.3 — in an intron of XPO7.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Telomere length (principal component 1) — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Telomere length (principal component 1).
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Telomere length (principal component 1) compared to the general population.
Source

Questions about rs878873

What is rs878873?

rs878873 is a single position in the genome, in or near the XPO7 gene. Published research associates it with telomere length (principal component 1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs878873 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs878873 come from?

GWAS Catalog, Nature genetics 2024, PMID:39192095. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Telomere length (principal component 1) (rs878873). MyGeneLog™. https://www.mygenelog.com/variants/rs878873

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