0 1622111Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others11Total16Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 5,539 European ancestry cases, 20,169 European ancestry controls; replicated in 6,768 European ancestry cases, 8,806 European ancestry controls.
The effect
Each copy of the C allele carried 1.16 times the odds of Rheumatoid arthritis (95% confidence interval 1.12-1.2); p = 1 × 10−16.
How common The C allele had a frequency of about 30% in the people studied.
Where it sits Chromosome 4, band 4p15.2 — between genes, 1.6 kb from LINC02357.
What each result means
C/CTwo copies of the version the research linked to Rheumatoid arthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Rheumatoid arthritis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Rheumatoid arthritis. This is the starting point the study compared everyone against.
rs874040 is a single position in the genome, in or near the near LINC02357 gene. Published research associates it with rheumatoid arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs874040 linked to?
On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs874040 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs874040 come from?
GWAS Catalog, Nature genetics 2010, PMID:20453842. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1622111Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others11Total16Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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