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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0164 higher (95% confidence interval 0.012-0.021); p = 5 × 10−13.
How common The C allele had a frequency of about 25% in the people studied.
Where it sits Chromosome 4, band 4q31.3 — between genes, 16.9 kb from SFRP2.
What each result means
C/CTwo copies of the version the research linked to FEV1 FVC ratio Z score (UKB data field 20258). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to FEV1 FVC ratio Z score (UKB data field 20258). That is a smaller link than two copies.
T/TNo copy of the version the research linked to FEV1 FVC ratio Z score (UKB data field 20258). This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs872453
What is rs872453?
rs872453 is a single position in the genome, in or near the near SFRP2 gene. Published research associates it with fev1 fvc ratio z score (ukb data field 20258). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs872453 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs872453 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs872453 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 111622Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot6Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total11Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
FEV1 FVC ratio Z score (UKB data field 20258) (rs872453). MyGeneLog™. https://www.mygenelog.com/variants/rs872453