MAPT · rs8712
Where this position leads
Condition: Alzheimer's Disease
What the study found
Who was studied 75,638 European ancestry cases, 1,043,805 European ancestry controls.
The effect Each copy of the G allele carried 0.93 times the odds of Alzheimer's disease or related dementias (95% confidence interval 0.92-0.95); p = 9 × 10−16.
How common The G allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 17, band 17q21.31 — in the 3′ untranslated region of MAPT.
What ClinVar records
Classification
Benign for MAPT-Related Spectrum Disorders; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-01-13.
ClinVar record 323657 NM_001377265.1(MAPT):c.*334A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs8712 is a single position in the genome, in or near the MAPT gene. Published research associates it with alzheimer's disease or related dementias. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2026, PMID:42237039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alzheimer's disease or related dementias (rs8712). MyGeneLog™. https://www.mygenelog.com/variants/rs8712