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Hereditary cancer-predisposing syndrome

ATM · rs866769874

Where this position leads

Condition: Hereditary Cancer-predisposing Syndrome

Drug: Metformin

rs866769874 Condition: Hereditary Cancer-predisposing Syndrome Hereditary Cancer-predisposing Syndrome Condition Drug: Metformin Metformin Drug rs866769874 rs866769874 ATM

Strength of the evidence

4 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 3 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Likely pathogenic for Hereditary cancer-predisposing syndrome, Ataxia-telangiectasia syndrome, ATM-related cancer predisposition; reviewed by expert panel (3 of 4 stars, 5 submitters), last evaluated 2025-06-11. ClinVar record 232110 NM_000051.4(ATM):c.9103C>T (p.Leu3035Phe)

Classification Uncertain significance for Ataxia-telangiectasia syndrome, Hereditary cancer-predisposing syndrome; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2022-06-15. ClinVar record 1356869 NM_000051.4(ATM):c.9103C>G (p.Leu3035Val)

Classification Uncertain significance for Hereditary cancer-predisposing syndrome; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2025-03-20. ClinVar record 482645 NM_000051.4(ATM):c.9103C>A (p.Leu3035Ile)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version ClinVar lists as likely disease-causing for Hereditary cancer-predisposing syndrome. This is the usual result. (ClinVar VCV000232110, reviewed by expert panel)
C/T One copy of the version ClinVar lists as likely disease-causing for Hereditary cancer-predisposing syndrome. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. (ClinVar VCV000232110, reviewed by expert panel)
T/T Two copies of the version ClinVar lists as likely disease-causing for Hereditary cancer-predisposing syndrome. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. (ClinVar VCV000232110, reviewed by expert panel)

Source: ClinVar VCV000232110, reviewed by expert panel

Questions about rs866769874

What is rs866769874?

rs866769874 is a single position in the genome, in or near the ATM gene. Published research associates it with hereditary cancer-predisposing syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs866769874 linked to?

On MyGeneLog this position is linked to Hereditary Cancer-predisposing Syndrome. The research behind each link, and its sources, are set out on that condition page.

Does rs866769874 affect how medicines work?

ATM carries pharmacogenomic findings for Metformin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs866769874 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs866769874 come from?

ClinVar VCV000232110, reviewed by expert panel. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Hereditary cancer-predisposing syndrome (rs866769874). MyGeneLog™. https://www.mygenelog.com/variants/rs866769874

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