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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 38,816 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.04 lower (95% confidence interval 0.02-0.06); p = 2 × 10−8.
How common The C allele had a frequency of about 72% in the people studied.
Where it sits Chromosome 19, band 19p13.12 — a synonymous change in PKN1.
What each result means
C/CTwo copies of the version the research linked to Kidney sinus volume. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Kidney sinus volume. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Kidney sinus volume. This is the starting point the study compared everyone against.
Kidney international · 2026 · PMID 41077127 · open access
Questions about rs8598
What is rs8598?
rs8598 is a single position in the genome, in or near the PKN1 gene. Published research associates it with kidney sinus volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs8598 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8598 come from?
GWAS Catalog, Kidney international 2026, PMID:41077127. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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