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Primary biliary cholangitis

TMEM163 · rs859767

Where this position leads

Condition: Primary Biliary Cholangitis

rs859767 Condition: Primary Biliary Cholangitis Primary Biliary Cholangitis Condition rs859767 rs859767 TMEM163

What the study found

Who was studied 8,021 European ancestry cases, 16,489 European ancestry controls, 2,495 East Asian ancestry cases, 4,283 East Asian ancestry controls.

The effect Each copy of the G allele shifted the measure 0.163 lower (95% confidence interval 0.12-0.2); p = 9 × 10−16.

Where it sits Chromosome 2, band 2q21.3 — in an intron of TMEM163.

What each result means

A/A No copy of the version the research linked to Primary biliary cholangitis. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Primary biliary cholangitis. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Primary biliary cholangitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs859767

What is rs859767?

rs859767 is a single position in the genome, in or near the TMEM163 gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs859767 linked to?

On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs859767 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs859767 come from?

GWAS Catalog, Journal of hepatology 2021, PMID:34033851. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Primary biliary cholangitis (rs859767). MyGeneLog™. https://www.mygenelog.com/variants/rs859767

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