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Blood protein levels

SHBG · rs858519

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 3,200 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.54 lower (95% confidence interval 0.5-0.59); p = 1 × 10⁻¹¹¹.

How common The T allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 17, band 17p13.1 — in an intron of SHBG.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Blood protein levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Blood protein levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Blood protein levels compared to the general population.

Source

Co-regulatory networks of human serum proteins link genetics to disease

Emilsson V, Ilkov M, Lamb JR, Finkel N, Gudmundsson EF, Pitts R, Hoover H, Gudmundsdottir V, Horman SR, Horman SR, Aspelund T, Shu L

and 17 more — show all

Trifonov V, Sigurdsson S, Manolescu A, Zhu J, Olafsson Ö, Jakobsdottir J, Lesley SA, To J, Zhang J, Harris TB, Launer LJ, Zhang B, Eiriksdottir G, Yang X, Orth AP, Jennings LL, Gudnason V

Science (New York, N.Y.) · 2018 · PMID 30072576

Questions about rs858519

What is rs858519?

rs858519 is a single position in the genome, in or near the SHBG gene. Published research associates it with blood protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs858519 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs858519 come from?

GWAS Catalog, Science (New York, N.Y.) 2018, PMID:30072576. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Blood protein levels (rs858519). MyGeneLog™. https://www.mygenelog.com/variants/rs858519

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