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Coronary dominance (left or co-dominant vs right dominant)

near SOST · rs851058

What the study found

Who was studied 7,708 European ancestry left or co-dominant individuals, 37,613 European ancestry right dominant individuals.

The effect Each copy of the A allele carried 1.11 times the odds of Coronary dominance (left or co-dominant vs right dominant) (95% confidence interval 1.07-1.15); p = 5 × 10−9.

How common The A allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 17, band 17q21.31 — between genes, 1.6 kb from SOST.

What each result means

A/A Two copies of the version the research linked to Coronary dominance (left or co-dominant vs right dominant). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Coronary dominance (left or co-dominant vs right dominant). That is a smaller link than two copies.
G/G No copy of the version the research linked to Coronary dominance (left or co-dominant vs right dominant). This is the starting point the study compared everyone against.
Source

Questions about rs851058

What is rs851058?

rs851058 is a single position in the genome, in or near the near SOST gene. Published research associates it with coronary dominance (left or co-dominant vs right dominant). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs851058 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs851058 come from?

GWAS Catalog, Cell 2025, PMID:40049164. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Coronary dominance (left or co-dominant vs right dominant) (rs851058). MyGeneLog™. https://www.mygenelog.com/variants/rs851058

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