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Height (maximum, inv-normal transformed)

FEZ2 · rs848602

Where this position leads

Condition: Height

rs848602 Condition: Height Height Condition rs848602 rs848602 FEZ2

What the study found

Who was studied 119,011 African American or Afro-Caribbean individuals, 57,810 Hispanic or Latin American individuals, 6,384 East Asian ancestry individuals, 424,305 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0439 higher (95% confidence interval 0.037-0.051); p = 5 × 10−37.

How common The G allele had a frequency of about 62% in the people studied.

Where it sits Chromosome 2, band 2p22.2 — inside FEZ2.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Height (maximum, inv-normal transformed) — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Height (maximum, inv-normal transformed).
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Height (maximum, inv-normal transformed) compared to the general population.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs848602

What is rs848602?

rs848602 is a single position in the genome, in or near the FEZ2 gene. Published research associates it with height (maximum, inv-normal transformed). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs848602 linked to?

On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.

Does having rs848602 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs848602 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Height (maximum, inv-normal transformed) (rs848602). MyGeneLog™. https://www.mygenelog.com/variants/rs848602

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