7 40323612518Reads by AI crawlersClaude3ChatGPT2Google · Gemini0Perplexity3Meta AI6Microsoft · Copilot1Amazon2Apple5China (ByteDance, Huawei, Baidu…)0Others18Total40Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 2,116 European ancestry cases, 24,626 European ancestry controls; replicated in 1, 389 European ancestry cases, 79,727 European ancestry controls, 759 South Asian ancestry cases, 8,009 South Asian ancestry controls, 405 African ancestry cases, 4,185 African ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.233 higher (95% confidence interval 0.18-0.28); p = 2 × 10−20.
Where it sits Chromosome 5, band 5q23.1 — between genes, 2.8 kb from SRFBP1.
What each result means
G/GNo copy of the version the research linked to Keratoconus. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Keratoconus. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Keratoconus. That is the strongest link of the three results. A link in a study is not a diagnosis.
Communications biology · 2021 · PMID 33649486 · open access
Questions about rs840464
What is rs840464?
rs840464 is a single position in the genome, in or near the SRFBP1 gene. Published research associates it with keratoconus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs840464 linked to?
On MyGeneLog this position is linked to Keratoconus. The research behind each link, and its sources, are set out on that condition page.
Does having rs840464 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs840464 come from?
GWAS Catalog, Commun Biol 2021, PMID:33649486. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
7 40323612518Reads by AI crawlersClaude3ChatGPT2Google · Gemini0Perplexity3Meta AI6Microsoft · Copilot1Amazon2Apple5China (ByteDance, Huawei, Baidu…)0Others18Total40Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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