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Who was studied 88,192 cases, 162,544 controls; replicated in 34,541 cases, 261,984 controls.
The effect
Each copy of the A allele shifted the measure 0.0322 lower (95% confidence interval 0.021-0.044); p = 2 × 10−8.
How common The A allele had a frequency of about 61% in the people studied.
Where it sits Chromosome 5, band 5q11.2 — between genes, 3.3 kb from LOC105378980.
What each result means
A/ATwo copies of the version the research linked to Coronary artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Coronary artery disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Coronary artery disease. This is the starting point the study compared everyone against.
Circulation research · 2018 · PMID 29212778 · open access
Questions about rs832540
What is rs832540?
rs832540 is a single position in the genome, in or near the MAP3K1 gene. Published research associates it with coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs832540 linked to?
On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs832540 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs832540 come from?
GWAS Catalog, Circ Res 2017, PMID:29212778. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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