Standard

Body mass index

near RNU2-54P · rs830463

Where this position leads

What the study found

Who was studied 44,540 European ancestry individuals, 22,488 African ancestry individuals, 248 Barbadian ancestry individuals, 1,241 Asian ancestry individuals, 3,840 East Asian ancestry individuals, 15,242 Hispanic or Latin American individuals, 1,274 Samoan ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0305 higher (95% confidence interval 0.021-0.04); p = 7 × 10⁻¹⁰.

How common The G allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 8, band 8q21.13 — between genes, 196.9 kb from RNU2-54P.

What each result means

A/A No copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Body mass index. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele

Zhang X, Brody JA, Graff M, Highland HM, Chami N, Xu H, Wang Z, Ferrier KR, Chittoor G, Josyula NS, Meyer M, Gupta S

and 113 more — show all

Li X, Li Z, Allison MA, Becker DM, Bielak LF, Bis JC, Boorgula MP, Bowden DW, Broome JG, Buth EJ, Carlson CS, Chang KM, Chavan S, Chiu YF, Chuang LM, Conomos MP, DeMeo DL, Du M, Duggirala R, Eng C, Fohner AE, Freedman BI, Garrett ME, Guo X, Haiman C, Heavner BD, Hidalgo B, Hixson JE, Ho YL, Hobbs BD, Hu D, Hui Q, Hwu CM, Jackson RD, Jain D, Kalyani RR, Kardia SLR, Kelly TN, Lange EM, LeNoir M, Li C, Le Marchand L, McDonald MN, McHugh CP, Morrison AC, Naseri T, O'Connell J, O'Donnell CJ, Palmer ND, Pankow JS, Perry JA, Peters U, Preuss MH, Rao DC, Regan EA, Reupena SM, Roden DM, Rodriguez-Santana J, Sitlani CM, Smith JA, Tiwari HK, Vasan RS, Wang Z, Weeks DE, Wessel J, Wiggins KL, Wilkens LR, Wilson PWF, Yanek LR, Yoneda ZT, Zhao W, Zhao W, Zöllner S, Arnett DK, Ashley-Koch AE, Barnes KC, Blangero J, Boerwinkle E, Burchard EG, Carson AP, Chasman DI, Ida Chen YD, Curran JE, Fornage M, Gordeuk VR, He J, Heckbert SR, Hou L, Irvin MR, Kooperberg C, Minster RL, Mitchell BD, Nouraie M, Psaty BM, Raffield LM, Reiner AP, Rich SS, Rotter JI, Benjamin Shoemaker M, Smith NL, Taylor KD, Telen MJ, Weiss ST, Zhang Y, Heard-Costa N, Sun YV, Lin X, Cupples LA, Lange LA, Liu CT, Loos RJF, North KE, Justice AE

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

Nature communications · 2025 · PMID 40216759 · open access

Questions about rs830463

What is rs830463?

rs830463 is a single position in the genome, in or near the near RNU2-54P gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs830463 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.

Does having rs830463 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs830463 come from?

GWAS Catalog, Nature communications 2025, PMID:40216759. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs830463). MyGeneLog™. https://www.mygenelog.com/variants/rs830463

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