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White matter hyperintensities

KLHL24 · rs830179

What the study found

Who was studied 30,708 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 8.51 z score higher; p = 2 × 10−17.

Where it sits Chromosome 3, band 3q27.1 — in an intron of KLHL24.

What each result means

A/A No copy of the version the research linked to White matter hyperintensities. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to White matter hyperintensities. That is a smaller link than two copies.
G/G Two copies of the version the research linked to White matter hyperintensities. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs830179

What is rs830179?

rs830179 is a single position in the genome, in or near the KLHL24 gene. Published research associates it with white matter hyperintensities. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs830179 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs830179 come from?

GWAS Catalog, Nature communications 2024, PMID:38890310. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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White matter hyperintensities (rs830179). MyGeneLog™. https://www.mygenelog.com/variants/rs830179

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