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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 140,886 European ancestry individuals; replicated in 190,318 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.236 higher (95% confidence interval 0.18-0.29); p = 3 × 10−13.
How common The T allele had a frequency of about 38% in the people studied.
Where it sits Chromosome 11, band 11q23.3 — in the 3′ untranslated region of CEP164.
What each result means
C/CNo copy of the version the research linked to Pulse pressure. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Pulse pressure. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Pulse pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2017 · PMID 28135244 · open access
Questions about rs8258
What is rs8258?
rs8258 is a single position in the genome, in or near the CEP164 gene. Published research associates it with pulse pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs8258 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8258 come from?
GWAS Catalog, Nature genetics 2017, PMID:28135244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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