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Smoking behaviour (cigarettes smoked per day)

CYP2A6 · rs8192726

Where this position leads

Condition: Smoking Behaviour and Nicotine Dependence

Drug: Smoking cessation medicines

rs8192726 Condition: Smoking Behaviour and Nicotine Dependence Smoking Behaviour and Nicotine Dependence Condition Drug: Smoking cessation medicines Smoking cessation medicines Drug rs8192726 rs8192726 CYP2A6

What the study found

Who was studied up to 377,334 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0393 lower (95% confidence interval 0.03-0.049); p = 8 × 10−16.

How common The A allele had a frequency of about 7% in the people studied.

Where it sits Chromosome 19, band 19q13.2 — a synonymous change in CYP2A6.

What each result means

A/A Two copies of the version the research linked to Smoking behaviour (cigarettes smoked per day). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Smoking behaviour (cigarettes smoked per day). That is a smaller link than two copies.
C/C No copy of the version the research linked to Smoking behaviour (cigarettes smoked per day). This is the starting point the study compared everyone against.
Source
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, Datta G, Davila-Velderrain J, McGuire D, Tian C, Zhan X, Choquet H
and 111 more — show all
Docherty AR, Faul JD, Foerster JR, Fritsche LG, Gabrielsen ME, Gordon SD, Haessler J, Hottenga JJ, Huang H, Jang SK, Jansen PR, Ling Y, Mägi R, Matoba N, McMahon G, Mulas A, Orrù V, Palviainen T, Pandit A, Reginsson GW, Skogholt AH, Smith JA, Taylor AE, Turman C, Willemsen G, Young H, Young KA, Zajac GJM, Zhao W, Zhou W, Bjornsdottir G, Boardman JD, Boehnke M, Boomsma DI, Chen C, Cucca F, Davies GE, Eaton CB, Ehringer MA, Esko T, Fiorillo E, Gillespie NA, Gudbjartsson DF, Haller T, Harris KM, Heath AC, Hewitt JK, Hickie IB, Hokanson JE, Hopfer CJ, Hunter DJ, Iacono WG, Johnson EO, Kamatani Y, Kardia SLR, Keller MC, Kellis M, Kooperberg C, Kraft P, Krauter KS, Laakso M, Lind PA, Loukola A, Lutz SM, Madden PAF, Martin NG, McGue M, McQueen MB, Medland SE, Metspalu A, Mohlke KL, Nielsen JB, Okada Y, Peters U, Polderman TJC, Posthuma D, Reiner AP, Rice JP, Rimm E, Rose RJ, Runarsdottir V, Stallings MC, Stančáková A, Stefansson H, Thai KK, Tindle HA, Tyrfingsson T, Wall TL, Weir DR, Weisner C, Whitfield JB, Winsvold BS, Yin J, Zuccolo L, Bierut LJ, Hveem K, Lee JJ, Munafò MR, Saccone NL, Willer CJ, Cornelis MC, David SP, Hinds DA, Jorgenson E, Kaprio J, Stitzel JA, Stefansson K, Thorgeirsson TE, Abecasis G, Liu DJ, Vrieze S
23andMe Research Team · HUNT All-In Psychiatry
Nature genetics · 2019 · PMID 30643251 · open access

Questions about rs8192726

What is rs8192726?

rs8192726 is a single position in the genome, in or near the CYP2A6 gene. Published research associates it with smoking behaviour (cigarettes smoked per day). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8192726 linked to?

On MyGeneLog this position is linked to Smoking Behaviour and Nicotine Dependence. The research behind each link, and its sources, are set out on that condition page.

Does rs8192726 affect how medicines work?

CYP2A6 carries pharmacogenomic findings for Smoking cessation medicines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs8192726 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8192726 come from?

GWAS Catalog, Nature genetics 2019, PMID:30643251. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Smoking behaviour (cigarettes smoked per day) (rs8192726). MyGeneLog™. https://www.mygenelog.com/variants/rs8192726

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