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Total testosterone levels

CHEK2 · rs8184986

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 230,454 European ancestry women.

The effect Each copy of the A allele shifted the measure 0.0234 higher (95% confidence interval 0.015-0.032); p = 2 × 10⁻⁸.

How common The A allele had a frequency of about 87% in the people studied.

Where it sits Chromosome 22, band 22q12.1 — in an intron of CHEK2.

What each result means

A/A Two copies of the version the research linked to Total testosterone levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/T One copy of the version the research linked to Total testosterone levels. That is a smaller link than two copies.

T/T No copy of the version the research linked to Total testosterone levels. This is the starting point the study compared everyone against.

Source

Using human genetics to understand the disease impacts of testosterone in men and women

Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, Erzurumluoglu AM, Hollis B

and 10 more — show all

O'Mara TA, McCarthy MI, Langenberg C, Easton DF, Wareham NJ, Burgess S, Murray A, Ong KK, Frayling TM, Perry JRB

Endometrial Cancer Association Consortium

Nature medicine · 2020 · PMID 32042192 · open access

Questions about rs8184986

What is rs8184986?

rs8184986 is a single position in the genome, in or near the CHEK2 gene. Published research associates it with total testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs8184986 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8184986 come from?

GWAS Catalog, Nature medicine 2020, PMID:32042192. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Total testosterone levels (rs8184986). MyGeneLog™. https://www.mygenelog.com/variants/rs8184986

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