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Blood protein levels

IL15RA · rs8177683

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 3,200 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.207 lower (95% confidence interval 0.16-0.26); p = 1 × 10⁻¹⁶.

How common The C allele had a frequency of about 60% in the people studied.

Where it sits Chromosome 10, band 10p15.1 — in an intron of IL15RA.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Blood protein levels compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Blood protein levels.

T/T Published research associates this genotype with typical/baseline likelihood of Blood protein levels — no copies of the reported risk allele.

Source

Co-regulatory networks of human serum proteins link genetics to disease

Emilsson V, Ilkov M, Lamb JR, Finkel N, Gudmundsson EF, Pitts R, Hoover H, Gudmundsdottir V, Horman SR, Horman SR, Aspelund T, Shu L

and 17 more — show all

Trifonov V, Sigurdsson S, Manolescu A, Zhu J, Olafsson Ö, Jakobsdottir J, Lesley SA, To J, Zhang J, Harris TB, Launer LJ, Zhang B, Eiriksdottir G, Yang X, Orth AP, Jennings LL, Gudnason V

Science (New York, N.Y.) · 2018 · PMID 30072576

Questions about rs8177683

What is rs8177683?

rs8177683 is a single position in the genome, in or near the IL15RA gene. Published research associates it with blood protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs8177683 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8177683 come from?

GWAS Catalog, Science (New York, N.Y.) 2018, PMID:30072576. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Blood protein levels (rs8177683). MyGeneLog™. https://www.mygenelog.com/variants/rs8177683

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