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Junctional adhesion molecule B levels

ABO · rs8176725

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹¹, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 2,935 Qatari ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.268 higher (95% confidence interval 0.19-0.34); p = 8 × 10⁻¹².

How common The A allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 9, band 9q34.2 — in an intron of ABO.

What each result means

A/A Two copies of the version the research linked to Junctional adhesion molecule B levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Junctional adhesion molecule B levels. That is a smaller link than two copies.

G/G No copy of the version the research linked to Junctional adhesion molecule B levels. This is the starting point the study compared everyone against.

Source

Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations

Thareja G, Belkadi A, Arnold M, Albagha OME, Graumann J, Schmidt F, Grallert H, Peters A, Gieger C, Consortium TQGPR, Suhre K

Human molecular genetics · 2023 · PMID 36168886 · open access

Questions about rs8176725

What is rs8176725?

rs8176725 is a single position in the genome, in or near the ABO gene. Published research associates it with junctional adhesion molecule b levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs8176725 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8176725 come from?

GWAS Catalog, Human molecular genetics 2023, PMID:36168886. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Junctional adhesion molecule B levels (rs8176725). MyGeneLog™. https://www.mygenelog.com/variants/rs8176725

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