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Its strongest genetic-study result is p = 10−139, with 44 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 5,425 African ancestry cases, 6,891 African ancestry controls.
The effect
Each copy of the A allele carried 1.28 times the odds of Malaria (95% confidence interval 1.19-1.39); p = 9 × 10−10.
Where it sits Chromosome 9, band 9q34.2 — in an intron of ABO.
What each result means
A/ATwo copies of the version the research linked to Malaria. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Malaria. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Malaria. This is the starting point the study compared everyone against.
PLoS genetics · 2013 · PMID 23717212 · open access
Questions about rs8176722
What is rs8176722?
rs8176722 is a single position in the genome, in or near the ABO gene. Published research associates it with malaria. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs8176722 linked to?
On MyGeneLog this position is linked to Malaria. The research behind each link, and its sources, are set out on that condition page.
Does having rs8176722 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8176722 come from?
GWAS Catalog, PLoS Genet 2013, PMID:23717212. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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