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Triglyceride levels

GCKR · rs814295

Where this position leads

Condition: High Triglycerides

rs814295 Condition: High Triglycerides High Triglycerides Condition rs814295 rs814295 GCKR

What the study found

Who was studied 18,421 East Asian ancestry individuals; replicated in 38,060 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.102 higher (95% confidence interval 0.08-0.124); p = 5 × 10−20.

How common The A allele had a frequency of about 67% in the people studied.

Where it sits Chromosome 2, band 2p23.3 — in an intron of GCKR.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Triglyceride levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Triglyceride levels.
G/G Published research associates this genotype with typical/baseline likelihood of Triglyceride levels — no copies of the reported risk allele.
Source
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels
Spracklen CN, Chen P, Kim YJ, Wang X, Cai H, Li S, Long J, Wu Y, Wang YX, Takeuchi F, Wu JY, Jung KJ
and 103 more — show all
Hu C, Akiyama K, Zhang Y, Moon S, Johnson TA, Li H, Dorajoo R, He M, Cannon ME, Roman TS, Salfati E, Lin KH, Guo X, Sheu WHH, Absher D, Adair LS, Assimes TL, Aung T, Cai Q, Chang LC, Chen CH, Chien LH, Chuang LM, Chuang SC, Du S, Fan Q, Fann CSJ, Feranil AB, Friedlander Y, Gordon-Larsen P, Gu D, Gui L, Guo Z, Heng CK, Hixson J, Hou X, Hsiung CA, Hu Y, Hwang MY, Hwu CM, Isono M, Juang JJ, Khor CC, Kim YK, Koh WP, Kubo M, Lee IT, Lee SJ, Lee WJ, Liang KW, Lim B, Lim SH, Liu J, Nabika T, Pan WH, Peng H, Quertermous T, Sabanayagam C, Sandow K, Shi J, Sun L, Tan PC, Tan SP, Taylor KD, Teo YY, Toh SA, Tsunoda T, van Dam RM, Wang A, Wang F, Wang J, Wei WB, Xiang YB, Yao J, Yuan JM, Zhang R, Zhao W, Chen YI, Rich SS, Rotter JI, Wang TD, Wu T, Lin X, Han BG, Tanaka T, Cho YS, Katsuya T, Jia W, Jee SH, Chen YT, Kato N, Jonas JB, Cheng CY, Shu XO, He J, Zheng W, Zheng W, Wong TY, Huang W, Kim BJ, Tai ES, Mohlke KL, Sim X
Human molecular genetics · 2017 · PMID 28334899

Questions about rs814295

What is rs814295?

rs814295 is a single position in the genome, in or near the GCKR gene. Published research associates it with triglyceride levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs814295 linked to?

On MyGeneLog this position is linked to High Triglycerides. The research behind each link, and its sources, are set out on that condition page.

Does having rs814295 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs814295 come from?

GWAS Catalog, Hum Mol Genet 2017, PMID:28334899. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Triglyceride levels (rs814295). MyGeneLog™. https://www.mygenelog.com/variants/rs814295

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