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Weight

LARGE1 · rs8135715

Where this position leads

Condition: Obesity and Body Weight

rs8135715 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs8135715 rs8135715 LARGE1

What the study found

Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0285 higher (95% confidence interval 0.021-0.036); p = 1 × 10−14.

Where it sits Chromosome 22, band 22q12.3 — in an intron of LARGE1.

What each result means

A/A Two copies of the version the research linked to Weight. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Weight. That is a smaller link than two copies.
G/G No copy of the version the research linked to Weight. This is the starting point the study compared everyone against.
Source
Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures
Jee YH, Wang Y, Jung KJ, Lee JY, Kimm H, Duan R, Price AL, Martin AR, Kraft P
Nature communications · 2025 · PMID 40436827 · open access

Questions about rs8135715

What is rs8135715?

rs8135715 is a single position in the genome, in or near the LARGE1 gene. Published research associates it with weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8135715 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs8135715 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8135715 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Weight (rs8135715). MyGeneLog™. https://www.mygenelog.com/variants/rs8135715

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