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Adventurousness

TCF4 · rs812738

Where this position leads

What the study found

Who was studied 557,923 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0129 higher (95% confidence interval 0.0089-0.0169); p = 4 × 10⁻¹⁰.

How common The T allele had a frequency of about 67% in the people studied.

Where it sits Chromosome 18, band 18q21.2 — in an intron of LOC105372130.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Adventurousness — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Adventurousness.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Adventurousness compared to the general population.

Source

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Karlsson Linnér R, Biroli P, Kong E, Meddens SFW, Wedow R, Fontana MA, Lebreton M, Tino SP, Abdellaoui A, Hammerschlag AR, Nivard MG, Okbay A

and 80 more — show all

Rietveld CA, Timshel PN, Trzaskowski M, Vlaming R, Zünd CL, Bao Y, Buzdugan L, Caplin AH, Chen CY, Eibich P, Fontanillas P, Gonzalez JR, Joshi PK, Karhunen V, Kleinman A, Levin RZ, Lill CM, Meddens GA, Muntané G, Sanchez-Roige S, Rooij FJV, Taskesen E, Wu Y, Zhang F, Auton A, Boardman JD, Clark DW, Conlin A, Dolan CC, Fischbacher U, Groenen PJF, Harris KM, Hasler G, Hofman A, Ikram MA, Jain S, Karlsson R, Kessler RC, Kooyman M, MacKillop J, Männikkö M, Morcillo-Suarez C, McQueen MB, Schmidt KM, Smart MC, Sutter M, Thurik AR, Uitterlinden AG, White J, Wit H, Yang J, Bertram L, Boomsma DI, Esko T, Fehr E, Hinds DA, Johannesson M, Kumari M, Laibson D, Magnusson PKE, Meyer MN, Navarro A, Palmer AA, Pers TH, Posthuma D, Schunk D, Stein MB, Svento R, Tiemeier H, Timmers PRHJ, Turley P, Ursano RJ, Wagner GG, Wilson JF, Gratten J, Lee JJ, Cesarini D, Benjamin DJ, Koellinger PD, Beauchamp JP

23and Me Research Team · eQTLgen Consortium · International Cannabis Consortium · Social Science Genetic Association Consortium

Nature genetics · 2019 · PMID 30643258

Questions about rs812738

What is rs812738?

rs812738 is a single position in the genome, in or near the TCF4 gene. Published research associates it with adventurousness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs812738 linked to?

On MyGeneLog this position is linked to Adventurousness. The research behind each link, and its sources, are set out on that condition page.

Does having rs812738 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs812738 come from?

GWAS Catalog, Nat Genet 2019, PMID:30643258. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Adventurousness (rs812738). MyGeneLog™. https://www.mygenelog.com/variants/rs812738

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