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Chronic hepatitis C infection

near MSRB1P1 · rs8113007

Where this position leads

Condition: Chronic Hepatitis C

rs8113007 Condition: Chronic Hepatitis C Chronic Hepatitis C Condition rs8113007 rs8113007 near MSRB1P1

What the study found

Who was studied 5,794 Japanese ancestry cases, 206,659 Japanese ancestry controls.

The effect Each copy of the T allele carried 1.43 times the odds of Chronic hepatitis C infection (95% confidence interval 1.339831592-1.522101518); p = 7 × 10−28.

How common The T allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 19, band 19q13.2 — between genes, 2.5 kb from MSRB1P1.

What each result means

A/A No copy of the version the research linked to Chronic hepatitis C infection. This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to Chronic hepatitis C infection. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Chronic hepatitis C infection. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T
and 77 more — show all
Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y
Nature genetics · 2020 · PMID 32514122

Questions about rs8113007

What is rs8113007?

rs8113007 is a single position in the genome, in or near the near MSRB1P1 gene. Published research associates it with chronic hepatitis c infection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8113007 linked to?

On MyGeneLog this position is linked to Chronic Hepatitis C. The research behind each link, and its sources, are set out on that condition page.

Does having rs8113007 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8113007 come from?

GWAS Catalog, Nature genetics 2020, PMID:32514122. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronic hepatitis C infection (rs8113007). MyGeneLog™. https://www.mygenelog.com/variants/rs8113007

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