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Who was studied 235,256 European ancestry individuals; replicated in 100,764 European ancestry individuals.
The effect
The reported allele is C; the catalogue records no effect size
; p = 5 × 10−34.
How common The C allele had a frequency of about 67% in the people studied.
Where it sits Chromosome 19, band 19q13.32 — inside MARK4.
What each result means
C/CTwo copies of the version the research linked to Platelet count. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Platelet count. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Platelet count. This is the starting point the study compared everyone against.
American journal of human genetics · 2021 · PMID 34469753
Questions about rs8112710
What is rs8112710?
rs8112710 is a single position in the genome, in or near the MARK4 gene. Published research associates it with platelet count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs8112710 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs8112710 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8112710 come from?
GWAS Catalog, American journal of human genetics 2021, PMID:34469753. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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