Sensitive

diarrhoeal disease at age 1

NTN5 · rs8111874

Where this position leads

Condition: Diarrhoeal Disease in Infancy

rs8111874 Condition: Diarrhoeal Disease in Infancy Diarrhoeal Disease in Infancy Condition rs8111874 rs8111874 NTN5

What the study found

Who was studied 2,693 European ancestry cases, 3,065 European ancestry controls; replicated in 2,302 European ancestry cases, 1,466 European ancestry controls.

The effect Each copy of the G allele carried 1.29 times the odds of diarrhoeal disease at age 1 (95% confidence interval 1.21-1.38); p = 8 × 10−14.

How common The G allele had a frequency of about 57% in the people studied.

Where it sits Chromosome 19, band 19q13.33 — in an intron of SEC1P.

What each result means

A/A No copy of the version the research linked to diarrhoeal disease at age 1. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to diarrhoeal disease at age 1. That is a smaller link than two copies.
G/G Two copies of the version the research linked to diarrhoeal disease at age 1. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs8111874

What is rs8111874?

rs8111874 is a single position in the genome, in or near the NTN5 gene. Published research associates it with diarrhoeal disease at age 1. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8111874 linked to?

On MyGeneLog this position is linked to Diarrhoeal Disease in Infancy. The research behind each link, and its sources, are set out on that condition page.

Does having rs8111874 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8111874 come from?

GWAS Catalog, Hum Mol Genet 2016, PMID:27559109. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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diarrhoeal disease at age 1 (rs8111874). MyGeneLog™. https://www.mygenelog.com/variants/rs8111874

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