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Sensitive

Hepatocellular carcinoma

near IFNL4 · rs8107030

Where this position leads

Condition: HBV-Related Hepatocellular Carcinoma

rs8107030 Condition: HBV-Related Hepatocellular Carcinoma HBV-Related Hepatocellular Carcinoma Condition rs8107030 rs8107030 near IFNL4

What the study found

Who was studied 1,866 Japanese ancestry cases, 195,745 Japanese ancestry controls.

The effect Each copy of the G allele carried 1.44 times the odds of Hepatocellular carcinoma (95% confidence interval 1.284266499-1.623333001); p = 8 × 10−10.

How common The G allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 19, band 19q13.2 — between genes, 0.2 kb from IFNL4.

What each result means

A/A No copy of the version the research linked to Hepatocellular carcinoma. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Hepatocellular carcinoma. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Hepatocellular carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T
and 77 more — show all
Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y
Nature genetics · 2020 · PMID 32514122

Questions about rs8107030

What is rs8107030?

rs8107030 is a single position in the genome, in or near the near IFNL4 gene. Published research associates it with hepatocellular carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8107030 linked to?

On MyGeneLog this position is linked to HBV-Related Hepatocellular Carcinoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs8107030 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8107030 come from?

GWAS Catalog, Nature genetics 2020, PMID:32514122. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hepatocellular carcinoma (rs8107030). MyGeneLog™. https://www.mygenelog.com/variants/rs8107030

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