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Hypertension

REXO1 · rs8102879

Where this position leads

Condition: Pulmonary Arterial Hypertension

rs8102879 Condition: Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension Condition rs8102879 rs8102879 REXO1

What the study found

Who was studied 394,626 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0416 lower (95% confidence interval 0.029-0.054); p = 4 × 10−12.

How common The A allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 19, band 19p13.3 — in an intron of REXO1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hypertension compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hypertension.
G/G Published research associates this genotype with typical/baseline likelihood of Hypertension — no copies of the reported risk allele.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs8102879

What is rs8102879?

rs8102879 is a single position in the genome, in or near the REXO1 gene. Published research associates it with hypertension. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8102879 linked to?

On MyGeneLog this position is linked to Pulmonary Arterial Hypertension. The research behind each link, and its sources, are set out on that condition page.

Does having rs8102879 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8102879 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hypertension (rs8102879). MyGeneLog™. https://www.mygenelog.com/variants/rs8102879

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