Sensitive

Prostate cancer

SPINT2 · rs8102476

Where this position leads

Condition: Prostate Cancer

rs8102476 Condition: Prostate Cancer Prostate Cancer Condition rs8102476 rs8102476 SPINT2

What the study found

Who was studied Up to 1,968 European ancestry cases, 35,382 European ancestry controls; replicated in Up to 11,806 European ancestry cases, 12,387 European ancestry controls.

The effect Each copy of the C allele carried 1.12 times the odds of Prostate cancer (95% confidence interval 1.08-1.15); p = 2 × 10−11.

How common The C allele had a frequency of about 54% in the people studied.

Where it sits Chromosome 19, band 19q13.2 — in a regulatory region of SPINT2.

What each result means

C/C Two copies of the version the research linked to Prostate cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Prostate cancer. That is a smaller link than two copies.
T/T No copy of the version the research linked to Prostate cancer. This is the starting point the study compared everyone against.
Source

Questions about rs8102476

What is rs8102476?

rs8102476 is a single position in the genome, in or near the SPINT2 gene. Published research associates it with prostate cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8102476 linked to?

On MyGeneLog this position is linked to Prostate Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs8102476 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8102476 come from?

GWAS Catalog, Nat Genet 2009, PMID:19767754. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Prostate cancer (rs8102476). MyGeneLog™. https://www.mygenelog.com/variants/rs8102476

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