Sensitive

Bladder cancer

CCNE1 · rs8102137

Where this position leads

What the study found

Who was studied 3,532 European ancestry cases, 5,120 European ancestry controls; replicated in 8,381 cases, 48,275 controls.

The effect Each copy of the C allele carried 1.13 times the odds of Bladder cancer (95% confidence interval 1.09-1.17); p = 2 × 10⁻¹¹.

How common The C allele had a frequency of about 33% in the people studied.

Where it sits Chromosome 19, band 19q12 — between genes, 5.5 kb from CCNE1.

What each result means

C/C Two copies of the version the research linked to Bladder cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Bladder cancer. That is a smaller link than two copies.

T/T No copy of the version the research linked to Bladder cancer. This is the starting point the study compared everyone against.

Source

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X, Figueroa JD, Real FX, Van Den Berg D, Matullo G, Baris D, Thun M, Kiemeney LA

and 98 more — show all

Vineis P, De Vivo I, Albanes D, Purdue MP, Rafnar T, Hildebrandt MA, Kiltie AE, Cussenot O, Golka K, Kumar R, Taylor JA, Mayordomo JI, Jacobs KB, Kogevinas M, Hutchinson A, Wang Z, Fu YP, Prokunina-Olsson L, Burdett L, Yeager M, Wheeler W, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Andriole G Jr, Grubb R 3rd, Black A, Jacobs EJ, Diver WR, Gapstur SM, Weinstein SJ, Virtamo J, Cortessis VK, Gago-Dominguez M, Pike MC, Stern MC, Yuan JM, Hunter DJ, McGrath M, Dinney CP, Czerniak B, Chen M, Yang H, Vermeulen SH, Aben KK, Witjes JA, Makkinje RR, Sulem P, Besenbacher S, Stefansson K, Riboli E, Brennan P, Panico S, Navarro C, Allen NE, Bueno-de-Mesquita HB, Trichopoulos D, Caporaso N, Landi MT, Canzian F, Ljungberg B, Tjonneland A, Clavel-Chapelon F, Bishop DT, Teo MT, Knowles MA, Guarrera S, Polidoro S, Ricceri F, Sacerdote C, Allione A, Cancel-Tassin G, Selinski S, Hengstler JG, Dietrich H, Fletcher T, Rudnai P, Gurzau E, Koppova K, Bolick SC, Godfrey A, Xu Z, Sanz-Velez JI, D García-Prats M, Sanchez M, Valdivia G, Porru S, Benhamou S, Hoover RN, Fraumeni JF Jr, Silverman DT, Chanock SJ

Nature genetics · 2010 · PMID 20972438 · open access

Questions about rs8102137

What is rs8102137?

rs8102137 is a single position in the genome, in or near the CCNE1 gene. Published research associates it with bladder cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8102137 linked to?

On MyGeneLog this position is linked to Bladder Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs8102137 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8102137 come from?

GWAS Catalog, Nat Genet 2010, PMID:20972438. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Bladder cancer (rs8102137). MyGeneLog™. https://www.mygenelog.com/variants/rs8102137

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