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Primary biliary cholangitis

PTPN2 · rs8098858

Where this position leads

Condition: Primary Biliary Cholangitis

rs8098858 Condition: Primary Biliary Cholangitis Primary Biliary Cholangitis Condition rs8098858 rs8098858 PTPN2

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Primary biliary cholangitis compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Primary biliary cholangitis.
C/C Published research associates this genotype with typical/baseline likelihood of Primary biliary cholangitis — no copies of the reported risk allele.
Source
A genome-wide association study identified PTPN2 as a population-specific susceptibility gene locus for primary biliary cholangitis
Hitomi Y, Ueno K, Aiba Y, Nishida N, Kono M, Sugihara M, Kawai Y, Kawashima M, Khor SS, Sugi K, Kouno H, Kohno H
and 52 more — show all
Naganuma A, Iwamoto S, Katsushima S, Furuta K, Nikami T, Mannami T, Yamashita T, Ario K, Komatsu T, Makita F, Shimada M, Hirashima N, Yokohama S, Nishimura H, Sugimoto R, Komura T, Ota H, Kojima M, Nakamuta M, Fujimori N, Yoshizawa K, Mano Y, Takahashi H, Hirooka K, Tsuruta S, Sato T, Yamasaki K, Kugiyama Y, Motoyoshi Y, Suehiro T, Saeki A, Matsumoto K, Nagaoka S, Abiru S, Yatsuhashi H, Ito M, Kawata K, Takaki A, Arai K, Arinaga-Hino T, Abe M, Harada M, Taniai M, Zeniya M, Ohira H, Shimoda S, Komori A, Tanaka A, Ishigaki K, Nagasaki M, Tokunaga K, Nakamura M
Hepatology (Baltimore, Md.) · 2024 · PMID 38652555

Questions about rs8098858

What is rs8098858?

rs8098858 is a single position in the genome, in or near the PTPN2 gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8098858 linked to?

On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs8098858 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8098858 come from?

GWAS Catalog, Hepatology (Baltimore, Md.) 2024, PMID:38652555. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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