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Glomerular filtration rate

NFATC1 · rs8096658

Where this position leads

Conditions: Kidney Function, Osteoarthritis

rs8096658 Condition: Kidney Function Kidney Function Condition Condition: Osteoarthritis Osteoarthritis Condition rs8096658 rs8096658 NFATC1

What the study found

Who was studied 23,553 European ancestry individuals, 23,536 Japanese individuals, 16,325 Hispanic individuals, 8,224 African American individuals.

The effect Each copy of the G allele shifted the measure 0.814 lower (95% confidence interval 0.54-1.09); p = 1 × 10−8.

Where it sits Chromosome 18, band 18q23 — in an intron of NFATC1.

What each result means

C/C No copy of the version the research linked to Glomerular filtration rate. This is the starting point the study compared everyone against.
C/G One copy of the version the research linked to Glomerular filtration rate. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Glomerular filtration rate. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs8096658

What is rs8096658?

rs8096658 is a single position in the genome, in or near the NFATC1 gene. Published research associates it with glomerular filtration rate. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8096658 linked to?

On MyGeneLog this position is linked to Kidney Function, Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs8096658 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8096658 come from?

GWAS Catalog, Am J Hum Genet 2016, PMID:27588450. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Glomerular filtration rate (rs8096658). MyGeneLog™. https://www.mygenelog.com/variants/rs8096658

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