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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 80,852 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0101 higher (95% confidence interval 0.0067-0.0134); p = 4 × 10−9.
How common The A allele had a frequency of about 80% in the people studied.
Where it sits Chromosome 18, band 18q21.2 — inside RAB27B.
What each result means
A/ATwo copies of the version the research linked to Life satisfaction. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Life satisfaction. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Life satisfaction. This is the starting point the study compared everyone against.
rs8089474 is a single position in the genome, in or near the RAB27B gene. Published research associates it with life satisfaction. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs8089474 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8089474 come from?
GWAS Catalog, Nat Genet 2019, PMID:30643256. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 121236Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)0Others6Total12Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Life satisfaction (rs8089474). MyGeneLog™. https://www.mygenelog.com/variants/rs8089474