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FEV1/FVC ratio

near VAPA · rs8089099

Where this position leads

Condition: Pulmonary Function (Lung Capacity)

What the study found

Who was studied 129,680 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0231 higher (95% confidence interval 0.015-0.031); p = 5 × 10⁻⁸.

Where it sits Chromosome 18, band 18p11.22 — between genes, 118.1 kb from VAPA.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of FEV1/FVC ratio compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with FEV1/FVC ratio.

G/G Published research associates this genotype with typical/baseline likelihood of FEV1/FVC ratio — no copies of the reported risk allele.

Source

Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction

He Y, Lu W, Jee YH, Shih MY, Wang Y, Tsuo K, Qian DC, Diao JA, Huang H, Patel CJ, Byun J, Pasaniuc B

and 6 more — show all

Atkinson EG, Amos CI, Feng YA, Moll M, Cho MH, Martin AR

Nature genetics · 2026 · PMID 41565855

Questions about rs8089099

What is rs8089099?

rs8089099 is a single position in the genome, in or near the near VAPA gene. Published research associates it with fev1/fvc ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8089099 linked to?

On MyGeneLog this position is linked to Pulmonary Function (Lung Capacity). The research behind each link, and its sources, are set out on that condition page.

Does having rs8089099 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8089099 come from?

GWAS Catalog, Nature genetics 2026, PMID:41565855. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

FEV1/FVC ratio (rs8089099). MyGeneLog™. https://www.mygenelog.com/variants/rs8089099

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