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Who was studied 434,794 European ancestry female individuals.
The effect
Each copy of the A allele shifted the measure 0.0137 lower (95% confidence interval 0.01-0.017); p = 5 × 10−14.
How common The A allele had a frequency of about 29% in the people studied.
Where it sits Chromosome 17, band 17q23.3 — in an intron of MAP3K3.
What each result means
A/ATwo copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Body mass index. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
Human molecular genetics · 2019 · PMID 30239722 · open access
Questions about rs8075273
What is rs8075273?
rs8075273 is a single position in the genome, in or near the MAP3K3 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs8075273 linked to?
On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution), Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.
Does having rs8075273 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8075273 come from?
GWAS Catalog, Hum Mol Genet 2018, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 3832117223215Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity1Meta AI7Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others15Total38Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Body mass index (rs8075273). MyGeneLog™. https://www.mygenelog.com/variants/rs8075273