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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0143 lower (95% confidence interval 0.01-0.018); p = 5 × 10−13.
How common The T allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 17, band 17p13.1 — in an intron of ZBTB4.
What each result means
A/ANo copy of the version the research linked to HDL cholesterol levels (UKB data field 30760). This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to HDL cholesterol levels (UKB data field 30760). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to HDL cholesterol levels (UKB data field 30760). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs8075009
What is rs8075009?
rs8075009 is a single position in the genome, in or near the ZBTB4 gene. Published research associates it with hdl cholesterol levels (ukb data field 30760). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs8075009 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs8075009 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8075009 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
HDL cholesterol levels (UKB data field 30760) (rs8075009). MyGeneLog™. https://www.mygenelog.com/variants/rs8075009