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Who was studied 228,926 European ancestry cases, 1,611,415 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.0236 higher (95% confidence interval 0.016-0.031); p = 3 × 10−10.
How common The C allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 17, band 17p13.2 — in an intron of ZZEF1.
What each result means
C/CTwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40645996 · open access
Questions about rs8074454
What is rs8074454?
rs8074454 is a single position in the genome, in or near the ZZEF1 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs8074454 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs8074454 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8074454 come from?
GWAS Catalog, Nature communications 2025, PMID:40645996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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