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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 37,432 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0482 SD units lower (95% confidence interval 0.034-0.062); p = 4 × 10−11.
How common The T allele had a frequency of about 46% in the people studied.
Where it sits Chromosome 16, band 16p13.3 — in an intron of NPRL3.
What each result means
C/CNo copy of the version the research linked to Macrocytic percentage of red cells. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Macrocytic percentage of red cells. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Macrocytic percentage of red cells. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2023 · PMID 37596262 · open access
Questions about rs8047658
What is rs8047658?
rs8047658 is a single position in the genome, in or near the NPRL3 gene. Published research associates it with macrocytic percentage of red cells. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs8047658 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8047658 come from?
GWAS Catalog, Nature communications 2023, PMID:37596262. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Macrocytic percentage of red cells (rs8047658). MyGeneLog™. https://www.mygenelog.com/variants/rs8047658