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Standard

Total cholesterol levels

DET1 · rs8043389

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.00955 higher (95% confidence interval 0.0068-0.0123); p = 1 × 10−8.

How common The T allele had a frequency of about 65% in the people studied.

Where it sits Chromosome 15, band 15q26.1 — in an intron of DET1.

How common each version is

GT
Korean KRGDB
G 26.2% · T 73.8%
Korean Korea4K
G 26.0% · T 74.0%
Korean Korea1K
G 25.7% · T 74.3%
Japanese ToMMo
G 31.6% · T 68.3%
Vietnamese
G 17.1% · T 82.9%
World gnomAD
G 26.7% · T 73.3%
World 1000 Genomes
G 20.4% · T 79.6%
World TOPMed
G 26.1% · T 73.9%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

G/G No copy of the version the research linked to Total cholesterol levels. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Total cholesterol levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Total cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Quoting this page

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Total cholesterol levels (rs8043389). MyGeneLog™. https://www.mygenelog.com/variants/rs8043389

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