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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 13,746 East Asian ancestry cases, 241,425 East Asian ancestry controls, 17,969 European ancestry cases, 702,230 European ancestry controls.
The effect
Each copy of the A allele carried 0.95 times the odds of Kidney stone disease (95% confidence interval 0.93-0.97); p = 3 × 10−8.
How common The A allele had a frequency of about 58% in the people studied.
Where it sits Chromosome 15, band 15q26.2 — in an intron of MCTP2.
What each result means
A/ATwo copies of the version the research linked to Kidney stone disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Kidney stone disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Kidney stone disease. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40216741 · open access
Questions about rs8042590
What is rs8042590?
rs8042590 is a single position in the genome, in or near the MCTP2 gene. Published research associates it with kidney stone disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs8042590 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8042590 come from?
GWAS Catalog, Nature communications 2025, PMID:40216741. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Kidney stone disease (rs8042590). MyGeneLog™. https://www.mygenelog.com/variants/rs8042590