Standard
Eosinophilic esophagitis
LOC283710 · rs8041227
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of Eosinophilic esophagitis — no copies of the reported risk allele.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Eosinophilic esophagitis.
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Eosinophilic esophagitis compared to the general population.
Source
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease
Kottyan LC,
Davis BP,
Sherrill JD,
Liu K,
Rochman M,
Kaufman K,
Weirauch MT,
Vaughn S,
Lazaro S,
Rupert AM,
Kohram M,
Stucke EM
and 17 more — show all
Kemme KA,
Magnusen A,
He H,
Dexheimer P,
Chehade M,
Wood RA,
Pesek RD,
Vickery BP,
Fleischer DM,
Lindbad R,
Sampson HA,
Mukkada VA,
Putnam PE,
Abonia JP,
Martin LJ,
Harley JB,
Rothenberg ME
Nature genetics · 2014 · PMID 25017104 · open access
Questions about rs8041227
What is rs8041227?
rs8041227 is a single position in the genome, in or near the LOC283710 gene. Published research associates it with eosinophilic esophagitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs8041227 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8041227 come from?
GWAS Catalog, Nat Genet 2014, PMID:25017104. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants