Standard
Airflow obstruction
AGPHD1 · rs8031948
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
G/G
Published research associates this genotype with typical/baseline likelihood of Airflow obstruction — no copies of the reported risk allele.
G/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Airflow obstruction.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Airflow obstruction compared to the general population.
Source
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction
Wilk JB,
Shrine NR,
Loehr LR,
Zhao JH,
Manichaikul A,
Lopez LM,
Smith AV,
Heckbert SR,
Smolonska J,
Tang W,
Loth DW,
Curjuric I
and 67 more — show all
Hui J,
Cho MH,
Latourelle JC,
Henry AP,
Aldrich M,
Bakke P,
Beaty TH,
Bentley AR,
Borecki IB,
Brusselle GG,
Burkart KM,
Chen TH,
Couper D,
Crapo JD,
Davies G,
Dupuis J,
Franceschini N,
Gulsvik A,
Hancock DB,
Harris TB,
Hofman A,
Imboden M,
James AL,
Khaw KT,
Lahousse L,
Launer LJ,
Litonjua A,
Liu Y,
Lohman KK,
Lomas DA,
Lumley T,
Marciante KD,
McArdle WL,
Meibohm B,
Morrison AC,
Musk AW,
Myers RH,
North KE,
Postma DS,
Psaty BM,
Rich SS,
Rivadeneira F,
Rochat T,
Rotter JI,
Soler Artigas M,
Starr JM,
Uitterlinden AG,
Wareham NJ,
Wijmenga C,
Zanen P,
Province MA,
Silverman EK,
Deary IJ,
Palmer LJ,
Cassano PA,
Gudnason V,
Barr RG,
Loos RJ,
Strachan DP,
London SJ,
Boezen HM,
Probst-Hensch N,
Gharib SA,
Hall IP,
O'Connor GT,
Tobin MD,
Stricker BH
American journal of respiratory and critical care medicine · 2012 · PMID 22837378
Questions about rs8031948
What is rs8031948?
rs8031948 is a single position in the genome, in or near the AGPHD1 gene. Published research associates it with airflow obstruction. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs8031948 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8031948 come from?
GWAS Catalog, Am J Respir Crit Care Med 2012, PMID:22837378. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants