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Pulse pressure

near CCN3 · rs80309268

What the study found

Who was studied 349,328 British ancestry individuals; replicated in 144,022 European ancestry,African ancestry,Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.04 lower (95% confidence interval 0.034-0.046); p = 8 × 10−54.

Where it sits Chromosome 8, band 8q24.12 — between genes, 30.3 kb from CCN3.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Pulse pressure — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Pulse pressure.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Pulse pressure compared to the general population.
Source

Questions about rs80309268

What is rs80309268?

rs80309268 is a single position in the genome, in or near the near CCN3 gene. Published research associates it with pulse pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs80309268 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs80309268 come from?

GWAS Catalog, Nature medicine 2024, PMID:38459180. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pulse pressure (rs80309268). MyGeneLog™. https://www.mygenelog.com/variants/rs80309268

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